Neurobehavioral Systems Research

Explosive Juveniles: Medical Management Without Antipsychotic Medication

Matthews, D., Fisher, L. & Matthews, G. (2012)
ANPA Abstracts at J Neuropsychiary Clin Neurosci, 24, 2, 256.

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This is a study of 91 explosive juveniles discharged from a residential treatment center without antipsychotic medications, but instead using a neuropsychiatric medication protocol consisting of anticonvulsant and dopaminergic medications (plus aftercare psychotherapy). The data suggest that, even without the use of antipsychotic medication, positive outcome (higher rates of improvement and fewer re-hospitalizations) for explosive youth can occur, six months post discharge from residential treatment, if outpatient physicians are compliant with the neuropsychiatric medication protocol.

Explosive Child Stabilized Without Antipsychotics: A Single Case Study Reversal Design

Fisher, L. & Matthews, D. (2012)
Poster presentation at the Texas Psychological Association, Austin, TX.

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This is a case study of a child with serious neuropsychiatric disorders who was diagnosed with Bipolar Disorder, Obsessive Compulsive Disorder, Attention Deficit Hyperactivity Disorder, Depression, Separation Anxiety, Neonatal Seizures, and a Developmental Encephalopathy secondary to subarachnoid hemorrhage. This reversal design case study, while not a controlled study, suggests that a high risk child with chronic irritability and explosive outbursts can be stabilized on an innovative neuropsychiatric medication protocol, without the use of antipsychotic medication, when combined with residential treatment and psychotherapy.

Event-Related Potentials in Juveniles with Impulsive Aggression: A Retrospective Chart Review Study

Fisher, W., Ceballos, N., Matthews, D., & Fisher, L. (2011)
Psychiatry Research, 187, 409-413

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This is a study of 91 explosive juveniles discharged from a residential treatment center without antipsychotic medications, but instead using a neuropsychiatric medication protocol consisting of anticonvulsant and dopaminergic medications (plus aftercare psychotherapy). The data suggest that, even without the use of antipsychotic medication, positive outcome (higher rates of improvement and fewer re-hospitalizations) for explosive youth can occur, six months post discharge from residential treatment, if outpatient physicians are compliant with the neuropsychiatric medication protocol.